Prince Frederik of Luxembourg dies from rare disease

Prince Frederik of Luxembourg has died after a lifelong battle with a rare genetic disorder known as POLG mitochondrial disease.

He passed away on March 1 in Paris, his family announced on the website of the POLG Foundation, which Frederik started in 2022.

“It is with a very heavy heart that my wife and I would like to inform you of the passing of our son, The POLG Foundation Founder and Creative Director, Frederik,” his father Prince Robert of Luxembourg wrote.

The foundation describes POLG as a “genetic mitochondrial disorder that robs the body’s cells of energy, in turn causing progressive multiple organ dysfunction and failure.”

It said the disease has no treatment or cure.

“Frederik and the POLG Foundation … are committed to finding therapies and a cure to save other patients from suffering what Frederik and our family have endured,” his father wrote.

Prince Frederik died a day after Rare Disease Day. He was in his early 20s.